Background: University students are at high risk for HPV infection, while HPV vaccination rates remain low. Message framing strategies may influence vaccination-related perceptions and intentions.
Objective: This study aims to compare the effects of gain- and loss-framed HPV vaccination messages on HPV risk perception, HPV knowledge, and vaccination intention among university students.
Methods: This randomized controlled experimental study includes university students from the health sciences faculty of a foundation university. Participants are assigned to gain-framed, loss-framed, and control groups. Data are collected using the Human Papillomavirus Knowledge Scale and the HPV Risk Perception Questionnaire. Statistical analyses include one-way ANOVA, two-way ANOVA, and Chi-square tests. The study is designed in accordance with CONSORT 2010 and EQUATOR Network reporting guidelines.
Keywords: message framing; gain-loss framing; human papillomavirus; vaccination