Brain Connectivity Changes in Glioma Patients During Treatment

The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as movement, language, or sensation, as well as the nerve fiber pathways that connect these areas. The main question this study aims to answer is: How do important brain areas and their connections adapt and reorganize over the course of glioma treatment? Patients with glioma will undergo repeated brain imaging examinations as part of their regular medical care. These images will be analyzed over time to observe changes in brain activity and structure during different stages of therapy. By studying these changes, researchers hope to gain new insights into the brain's ability to adapt (neuroplasticity) throughout the entire course of glioma treatment.

NCT Number	NCT07612917
Lead Sponsor	Johannes Kepler University of Linz Collaborators: Clinical Research Institute for Neurosciences, JKU Linz, Austria, Institute of Neuroradiology, Kepler University Hospital, Johannes Kepler University, Linz, Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University Linz, Department of Radiation Oncology, Ordensklinikum Linz, Barmherzige Schwestern, Linz
Conditions	Glioma (Any Grade) in the Brain, Gliomas, Malignant, fMRI Research, Neurocognitive Function
Enrollment	20 participants
Start Date	2026-05-01
Primary Completion	2029-09 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-13