A Multicenter, Prospective, Randomized Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on IVF-ET Outcomes in Infertile Patients With Non-recurrent Miscarriage

This study aims to evaluate the impact of hysteroscopic transcervical resection of the septum (TCRS) on fertility in infertile women without recurrent miscarriage, primarily assessing its effect on subsequent IVF-ET outcomes. The research attempts to answer: for infertile women with uterine septum planning to undergo IVF/ICSI (excluding preimplantation genetic diagnosis), does TCRS improve pregnancy outcomes (such as live birth rate, pregnancy rate, miscarriage rate, etc.) compared to non-surgical treatment (conservative observation), and to clarify the clinical value and safety of this surgical intervention.

NCT Number	NCT07611656
Lead Sponsor	The Third Xiangya Hospital of Central South University Collaborators: Obstetrics & Gynecology Hospital of Fudan University, Peking Union Medical College Hospital, Anhui Provincial Hospital, Maternal and Child Health Hospital of Hubei Province, The First People's Hospital of Yunnan, Tianjin Medical University General Hospital, Guangzhou First People's Hospital, Gansu Maternal and Child Health Hospital, Shandong University, Women's Hospital School Of Medicine Zhejiang University, The First Hospital of Jilin University, Beijing Tiantan Hospital, Tongji Hospital, Xijing Hospital, Southwest Hospital, China, Fu Xing Hospital, Capital Medical University
Conditions	Infertility and Miscarriage
Enrollment	236 participants
Start Date	2025-06-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2030-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-28