Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery

The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory performance in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS). While regional blocks like Erector Spinae Plane (ESP) block provide effective early analgesia, their effect typically diminishes after 8-12 hours, leading to potential 'rebound pain.' This study specifically investigates the period following the duration of the regional block's action. The primary goal is to evaluate which IV PCA protocol better controls pain (Visual Analog Scale scores) and supports better respiratory performance (measured by incentive spirometry) during the first 72 hours post-surgery

NCT Number	NCT07610408
Lead Sponsor	Ankara Etlik City Hospital
Conditions	Postoperative Pain After Thoracic Surgery, Postoperative Pain, Thoracic Surgery, Video Assisted, Patient Controlled Analgesia, Acute Pain
Enrollment	135 participants
Start Date	2026-06-02
Primary Completion	2026-09-27 (estimated)
Study Completion	2026-10-15 (estimated)
Updated on ClinicalTrials.gov	2026-06-09