Clinical, Oncologic, and Metabolic Effects of Pancreatic Mass Loss After Pancreatectomy in Non-Diabetic Patients

This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time. The study will include adults without diabetes before surgery who undergo pancreatic surgery as part of routine clinical care at Fondazione Policlinico Universitario A. Gemelli IRCCS. Researchers will study whether participants develop diabetes after surgery and whether this risk changes according to the type of pancreatic resection. Information from routine clinical care, metabolic tests, imaging, and pancreatic tissue samples collected during surgery may be used for research analyses.

NCT Number	NCT07608055
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS Collaborators: European Foundation for the Study of Diabetes
Conditions	Pancreatectomy, Diabetes Mellitus Type 2, Pancreatic Neoplasms
Enrollment	579 participants
Start Date	2026-05
Primary Completion	2037-05 (estimated)
Study Completion	2041-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-27