Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:

A vision-language model using preoperative MRI and clinical variables has been developed to simultaneously predict three key molecular markers in midline gliomas: H3K27M, IDH, and 1p/19q. This prospective multicenter study will validate the model's accuracy in preoperative molecular subtyping and its value in prognostic assessment and clinical decision-making across multiple neurosurgical centers.

NCT Number	NCT07608003
Lead Sponsor	Xiangya Hospital of Central South University
Conditions	Gliomas Harboring IDH1 and/or IDH2 Mutations, Glioma Glioblastoma Multiforme, Glioma of Brainstem, Glioma, Diffuse Midline, H3K27M-mutant, Glioma : Oligodendroglioma or Astrocytoma, Gliomas
Enrollment	500 participants
Start Date	2026-05-10
Primary Completion	2030-12-31 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-27