Clinical, Oncological and Metabolic Effects of Pancreatic Mass Loss After Partial, Near-total and Total Pancreatectomy in Patients With Preoperative Diabetes Mellitus

This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time. The study will include adults with diabetes before surgery who undergo pancreatic surgery as part of routine clinical care at Fondazione Policlinico Universitario A. Gemelli IRCCS. Researchers will study whether glycemic control worsens after surgery and whether this risk changes according to the type of pancreatic resection. The study will also examine changes in glucose metabolism, and cancer-related outcomes. Information from routine clinical care, metabolic tests, imaging, and pancreatic tissue samples collected during surgery may be used for research analyses.

NCT Number	NCT07607912
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS Collaborators: European Foundation for the Study of Diabetes
Conditions	Diabetes Mellitus Type 2, Pancreatectomy, Pancreatic Neoplasms
Enrollment	408 participants
Start Date	2026-05
Primary Completion	2037-05 (estimated)
Study Completion	2041-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-26