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Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data

Study acronym: META-RESPIRE
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Recruitment opened
    • Start date changed from estimate of May 27, 2026 to Jun 4, 2026
    • Site details revised
    v3
  2. Study description expanded, about 3 words
    • Study title expanded, about 2 words
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are: Can metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes? Participants will: Receive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.
Trial Details
NCT Number NCT07607080
Lead Sponsor Hospital del Mar Research Institute (IMIM)
Collaborators: Instituto de Salud Carlos III, Fundació La Marató de TV3, Hospital Universitari de Bellvitge, Hospital Universitari Joan XXIII de Tarragona., Parc Taulí Hospital Universitari, Institute for Bioengineering of Catalonia
Conditions
(from sponsor)		 Acute Hypoxemic Respiratory Failure
Related terms Respiratory Insufficiency
Enrollment 300 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov