Peripheral Blood CyTOF Immune Model for Cervical Lesion Detection in HPV16/18+ Women

This prospective, multicenter cohort study will recruit eligible HPV16/18-positive women from three tertiary hospitals in China. Peripheral blood samples and clinical data (cytology, HPV genotyping, colposcopy-directed biopsy) will be collected, followed by standardized mass cytometry (CyTOF) to develop and evaluate an immune model across cervical lesion grades.

NCT Number	NCT07606677
Lead Sponsor	Women's Hospital School Of Medicine Zhejiang University Collaborators: Jiaxing Maternity and Child Health Care Hospital, Ningbo Women & Children's Hospital, Zhejiang PuLuoTing Health Technology Co., Ltd.
Conditions	CIN 2/3, Cervical Cancer (Early Detection)
Enrollment	1,465 participants
Start Date	2026-05-15
Primary Completion	2027-03-31 (estimated)
Study Completion	2028-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-26