Blast Overpressure Longitudinal Study

The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel. The main questions it aims to answer are: What advanced brain imaging changes are related to clinical presentation after low-level blast exposure? What are the relationships between low-level blast exposure and common groups of symptoms after concussion? Participants will: * Undergo advanced brain imaging * Answer questionnaires * Complete clinical tests * Provide blood, urine, and saliva samples * Wear blast sensors

NCT Number	NCT07606651
Lead Sponsor	Uniformed Services University of the Health Sciences Collaborators: The Geneva Foundation, MIT Lincoln Laboratory
Conditions	Low-level Blast Exposure
Enrollment	250 participants
Start Date	2026-05
Primary Completion	2030-08 (estimated)
Study Completion	2030-08 (estimated)
Updated on ClinicalTrials.gov	2026-05-26