Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques

This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified randomization based on macular hole size to ensure balanced groups. The main goal is to determine which technique provides the highest anatomical closure rate on optical coherence tomography (OCT) and the best visual outcomes. Follow-up visits are scheduled at Day 7, Month 1, and Year 1 after surgery to assess OCT findings, visual acuity, safety outcomes, and the need for reoperation.

NCT Number	NCT07606404
Lead Sponsor	Kazakh Eye Research Institute
Conditions	Macular Holes
Enrollment	120 participants
Start Date	2026-05-25
Primary Completion	2027-05-27 (estimated)
Study Completion	2028-05-27 (estimated)
Updated on ClinicalTrials.gov	2026-06-02