Clinical Trial

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

Study acronym: DMR
Recruiting
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Summary
The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to: 1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term. 2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI 3. Assess patient-reported recovery and quality of life outcomes using validated tools. The study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.
Trial Details
NCT Number NCT07605715
Lead Sponsor Cedars-Sinai Medical Center
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions Degenerative Mitral Valve Disease
Enrollment 60 participants
Start Date 2025-02-19
Primary Completion 2027-08 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-05-26