Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age

Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF/ICSI cycles involving men aged 40 years or older

NCT Number	NCT07605182
Lead Sponsor	Vietnam Military Medical University Collaborators: National Hospital of Obstetrics and Gynecology, Tam Anh TP. Ho Chi Minh General Hospital, Viet-Belgium Andrology and Infertility Hospital, Phuong Chau International Hospital, Dong Do Hospital, Vinmec Healthcare System, Andrology and Fertility Hospital of Hanoi
Conditions	Male Infertility, Advanced Paternal Age, Assisted Reproductive Technology
Enrollment	378 participants
Start Date	2026-05-05
Primary Completion	2027-04-30 (estimated)
Study Completion	2027-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-22