Clinical Trial

Efficacy and Safety of Nefecon on Prevention of Relapse of IgA Nephropathy: a Randomized, Double-blinded, Placebo-Controlled Trial

Study acronym: NeFRIN
Not Yet Recruiting Phase 4
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Summary
IgA nephropathy (IgAN) is a chronic progressive kidney disease, and long-term control of proteinuria and prevention of relapse are crucial for delaying disease progression. Patients with IgAN who achieve proteinuria remission after receiving Nefecon for 9 months or longer still face the risk of proteinuria relapse after treatment discontinuation. This study is to evaluate the efficacy and safety of Nefecon 8 mg treatment for 15 months as a maintenance therapy for prevention of proteinuria relapse in proteinuria-remitted patients.
Trial Details
NCT Number NCT07604311
Lead Sponsor Nanfang Hospital, Southern Medical University
Conditions IgA Nephropathy (IgAN)
Enrollment 288 participants
Start Date 2026-05-01
Primary Completion 2028-12-01 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-22