Clinical Trial

The Effect of Different Intra-canal Medications on Postoperative Pain

Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and/or severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications. The study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2026-08-15 -> 2027-02-15 2026-07-22
minor Completion pushed: 2026-10 -> 2027-03-15 2026-07-22
Trial Details
NCT Number NCT07603934
Lead Sponsor Cairo University
Collaborators: Egyptian Russian University, Fayoum University
Conditions Pulp Necrosis, Apical Periodontitis
Enrollment 111 participants
Start Date 2025-12-15
Primary Completion 2027-02-15 (estimated)
Study Completion 2027-03-15 (estimated)
Updated on ClinicalTrials.gov 2026-07-21