Assessment of Venous Insufficiency and Clinical Features in Lipedema

Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.

NCT Number	NCT07603076
Lead Sponsor	Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Conditions	Lipedema, Venous Insufficiency, Venous Disease, Disability Physical
Enrollment	82 participants
Start Date	2026-06-20
Primary Completion	2026-07-30 (estimated)
Study Completion	2026-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-14