Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions

Chromocolonoscopy with acetic acid and indigo carmine has shown promise for improving the detection of sessile serrated lesions (SSLs), the precursor lesions responsible for a substantial proportion of interval colorectal cancers. Previous studies have demonstrated its potential to enhance visualization of both adenomatous and non-adenomatous polyps, particularly the subtle SSLs that are frequently missed during conventional white-light colonoscopy. However, high-quality randomized controlled trials comparing chromocolonoscopy with standard white-light imaging to provide definitive evidence on its efficacy for SSL detection are lacking. We therefore conducted a multicenter, prospective, randomized controlled trial to evaluate the diagnostic yield of acetic acid-indigo carmine chromocolonoscopy versus standard colonoscopy for SSL detection.

NCT Number	NCT07601217
Lead Sponsor	Changhai Hospital Collaborators: Heilongjiang Provicial Hospital, Ankang Central Hospital, Huadong Hospital Affiliated with Fudan University, Shanghai, The First Affiliated Hospital of Nanchang University, Yan'an People's Hospital, The Second Hospital of Hebei Medical University, Chongqing General Hospital, Guangzhou Medical University Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Shanxi Provincial People's Hospital, Shanghai Sixth Hospital, People's Hospital of Leshan, Sichuan Province, The Third People's Hospital of Chengdu, The Third People's Hospital of Jingdezhen, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Shandong Provincial Hospital
Conditions	Sessile Serrated Lesion
Enrollment	2,689 participants
Start Date	2026-06-15
Primary Completion	2028-11-15 (estimated)
Study Completion	2028-11-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-22