Clinical Trial

Periodontal Disease in Patients With Lynch Syndrome

Study acronym: SMILy_25
Not Yet Recruiting
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Record status
This record was last updated May 22, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
Trial Details
NCT Number NCT07600710
Lead Sponsor Rotundo Roberto
Conditions Lynch Syndrome, Periodontal Disease
Enrollment 25 participants
Start Date 2026-06-01
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-22