Clinical Trial

CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children

Study acronym: CHOSA
Not Yet Recruiting
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Summary
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior, learning, and quality of life. Children with moderate-to-severe OSA who cannot be treated with surgery are often prescribed Continuous Positive Airway Pressure (CPAP). CPAP uses a mask worn during sleep to deliver pressurized air and keep the airway open. Although CPAP is effective, many children have difficulty using it regularly because it can feel uncomfortable or hard to tolerate. This study compares CPAP with another treatment called High-Flow Nasal Cannula (HFNC). HFNC delivers warm, humidified air through soft nasal prongs and may be more comfortable and easier for children to use while still helping keep the airway open during sleep. Children aged 2 to 18 years with moderate-to-severe OSA will be randomly assigned to use either CPAP or HFNC at home during sleep for 3 months. The study will measure how much each treatment is used, how well it improves sleep-related symptoms and quality of life, how comfortable it is for children, and how it affects caregivers. The goal of this study is to find out whether HFNC is a comfortable and effective alternative to CPAP for treating obstructive sleep apnea in children.
Trial Details
NCT Number NCT07600333
Lead Sponsor The Hospital for Sick Children
Collaborators: Fisher and Paykel Healthcare
Conditions Obstructive Sleep Apnea (OSA)
Enrollment 258 participants
Start Date 2026-06-01
Primary Completion 2031-11 (estimated)
Study Completion 2031-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-20