Periprosthetic Joint Infection Bubble Study

Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injection of antibiotics and ultrasound-active microbubbles within 24 hours of their revision surgery. The fundamental hypothesis is that a decrease in re-infection rates of at least 24% can be achieved in the active group relative to controls.

NCT Number	NCT07599865
Lead Sponsor	Thomas Jefferson University Collaborators: National Institute of Allergy and Infectious Diseases (NIAID)
Conditions	Periprosthetic Joint Infection (PJI)
Enrollment	100 participants
Start Date	2026-06-30
Primary Completion	2028-06-01 (estimated)
Study Completion	2030-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-31