Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain

The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are: * Does topical capsaicin reduce pain intensity more effectively than topical diclofenac? * Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms? Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement. Participants will: * Apply the assigned topical medication four times daily for 7 days * Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1 * Complete pain-related questionnaires and functional jaw measurements during follow-up visits

NCT Number	NCT07598994
Lead Sponsor	Istanbul University Collaborators: The Scientific and Technological Research Council of Turkey
Conditions	Temporomandibular Disorders (TMD), Temporomandibular Pain
Enrollment	50 participants
Start Date	2025-08-28
Primary Completion	2026-04-06 (estimated)
Study Completion	2026-04-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-01