Clinical Trial

Target-Selected CAR-NK Cells (CD30, CD5, or Mesothelin) for Relapsed/Refractory B2 Thymoma or Thymic Carcinoma

Study acronym: SELECT-NK-THYM
Recruiting Phase 1/2
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Summary
This Phase 1/2 study evaluates the safety, tolerability, and preliminary efficacy of target-selected CAR-natural killer (CAR-NK) cells in adults with relapsed or refractory B2 thymoma or thymic carcinoma. Participants undergo centralized tumor antigen assessment (CD30, CD5, and mesothelin). Based on the dominant and clinically actionable antigen expression profile, each participant is assigned to one of three parallel cohorts (CD30-CAR-NK, CD5-CAR-NK, or mesothelin-CAR-NK). All cohorts use the same lymphodepleting conditioning regimen followed by CAR-NK infusion(s).
Trial Details
NCT Number NCT07598955
Lead Sponsor Beijing Biotech
Conditions B2 Thymoma, Thymic Carcinoma
Enrollment 36 participants
Start Date 2026-03-02
Primary Completion 2027-06-14 (estimated)
Study Completion 2028-04-17 (estimated)
Updated on ClinicalTrials.gov 2026-05-20