Pregabalin Phonophoresis and MET for Knee Osteoarthritis

Knee osteoarthritis (OA) is a common condition causing pain, stiffness, and difficulty walking. Many patients with advanced (Grade III) knee OA also experience neuropathic pain - burning, tingling, or electric shock sensations - which is harder to treat with standard physiotherapy. Oral pregabalin works for neuropathic pain but causes side effects like dizziness and drowsiness. This study tests whether delivering pregabalin through the skin using ultrasound (phonophoresis), combined with calf muscle stretching (Muscle Energy Technique), can reduce nerve pain and improve walking better than ultrasound alone.

NCT Number	NCT07598474
Lead Sponsor	University of Faisalabad
Conditions	Knee Osteoarthritis
Enrollment	35 participants
Start Date	2026-01-01
Primary Completion	2026-07-19 (estimated)
Study Completion	2026-07-19 (estimated)
Updated on ClinicalTrials.gov	2026-05-20