A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine delivery system (ENDS) power unit (2) and varying levels of access to tobacco-flavored, menthol-flavored, mint, or non-tobacco/non-menthol/non-mint-flavored cartridge-based e-liquids (collectively referred to as the investigational product) within their assigned study arm over a three-month (ninety-day) period.

NCT Number	NCT07598136
Lead Sponsor	RAI Services Company
Conditions	Smoking, Tobacco
Enrollment	1,280 participants
Start Date	2026-05-14
Primary Completion	2026-12-17 (estimated)
Study Completion	2027-01-21 (estimated)
Updated on ClinicalTrials.gov	2026-06-03