DYnamic decisioN Support for IntegrAting PrEP in Clinics for Young People in Alabama and Botswana

This study evaluates strategies to improve access to HIV prevention through the integration of pre-exposure prophylaxis (PrEP) into existing healthcare settings, rather than limiting delivery to specialty clinics. The study addresses barriers to PrEP uptake, including limited awareness, stigma, and restricted access, and recognizes that availability alone may not ensure initiation or sustained use. The study includes two components. First, a longitudinal cohort of current PrEP users will be followed to assess changes in access, preferences, and PrEP use over time in real-world settings. Second, a dynamic decision-support toolkit will be developed and evaluated to support patients and providers in PrEP-related decision-making. The toolkit will include patient- and provider-facing components to support clinical decision-making, improve risk understanding, and facilitate integration of PrEP into routine healthcare. The toolkit will be refined and beta-tested in selected healthcare facilities in Botswana and Alabama.

NCT Number	NCT07597824
Lead Sponsor	University of Alabama at Birmingham Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Beth Israel Deaconess Medical Center, Harvard School of Public Health (HSPH)
Conditions	HIV Infections, Contraception, PrEP
Enrollment	1,000 participants
Start Date	2026-06
Primary Completion	2031-12 (estimated)
Study Completion	2031-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-25