Clinical Trial

RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia

Study acronym: RELIEF
Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
The goal of this study is to evaluate if KRIYA-748 (RP-008) is safe, tolerable, and preliminary effective in treating trigeminal neuralgia (TN) when used in combination with varenicline tartrate. The study will also assess what doses of RP-008 are safe and tolerable for participants and how the severity of participants' TN pain and frequency of facial pain attacks are affected.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2028-12 -> 2029-02 2026-06-09
minor Completion pushed: 2028-12 -> 2029-02 2026-06-09
Trial Details
NCT Number NCT07596485
Lead Sponsor Kriya Therapeutics, Inc.
Conditions Trigeminal Neuralgia
Enrollment 24 participants
Start Date 2026-08
Primary Completion 2029-02 (estimated)
Study Completion 2029-02 (estimated)
Updated on ClinicalTrials.gov 2026-06-08