Clinical Trial

Abuse Liability of Two Modern Oral Nicotine Pouched Products

Not Yet Recruiting
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Record status
This record was last updated May 19, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a single-site, open-label, randomized, 4-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics \[PD\]) and plasma nicotine uptake (pharmacokinetics \[PK\]) during controlled monitored use and following ad libitum use of the study investigational products (IPs) by generally healthy smokers who are also users of smokeless tobacco.
Trial Details
NCT Number NCT07595055
Lead Sponsor RAI Services Company
Conditions Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Enrollment 40 participants
Start Date 2026-06-15
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-11-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-19