Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness

This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients. Adults receiving mechanical ventilation in the ICU will undergo ultrasound examinations of the median and tibial nerves on Days 1, 4, and 7. The study will evaluate whether early changes in nerve elasticity can predict ICU-AW, which is usually diagnosed later using a muscle strength score that requires patient cooperation.

NCT Number	NCT07594249
Lead Sponsor	First Affiliated Hospital of Wannan Medical College
Conditions	ICU-acquired Weakness, Critical Illness Polyneuropathy, Critical Illness Myopathy
Enrollment	98 participants
Start Date	2026-07-01
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-16