Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF

Clinical trial The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are: * Does hemoadsorption plus half-dose plasma exchange provide support to liver failure patients until recovery or transplant * What medical problems do participants have during the technique? Researchers will compare DPMAS plus half-dose plasma exchange with conventional treatment to evaluate a gain in recovery Participants will: * Be submitted to DPMAS plus half dose plasma exchange daily according to protocol. * Monitoring will be continuous in the ICU

NCT Number	NCT07593638
Lead Sponsor	Unidade Local de Saude do Nordeste
Conditions	Acute on Chronic Liver Failure (ACLF)
Enrollment	240 participants
Start Date	2026-07
Primary Completion	2027-12 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-18