Oat Flakes β-glucan on Glycemic Variability, Pancreatic Reserve, and Dyslipidemia Among Adolescents With Type 1 Diabetes

Chronic iron overload represents a significant morbidity in Transfusion dependent β-thalassemia (TDT) leading to various endocrine complications including diabetes. The GLP-1 receptor agonist (GLP-1RA) Dulaglutide has recently been approved for pediatric type 2 diabetes (T2D) treatment. Objectives: to assess the effect of Dulaglutide versus conventional insulin therapy on glycemic metrics, pancreatic reserve, dyslipidemia and ferritin among children and adolescents with TDT related diabetes.

NCT Number	NCT07593105
Lead Sponsor	Ain Shams University
Conditions	Type 1 Diabetes, Nutrition
Enrollment	60 participants
Start Date	2024-10-12
Primary Completion	2025-11-12 (estimated)
Study Completion	2026-02-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-18