Clinical Trial

Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution

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Summary
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance. The main questions it aims to answer are: Does creatine supplementation increase plasma volume and total body water during repeated heat exposure more than placebo? Does creatine supplementation improve exercise performance after heat acclimation more than placebo? Does creatine supplementation influence cardiovascular responses to heat stress? Researchers will compare a creatine supplementation group to a placebo group to determine whether creatine changes the magnitude of heat acclimation adaptations. Participants will: Complete baseline measurements of body composition, hydration, blood markers, and exercise performance. Consume either creatine monohydrate or a placebo supplement daily Complete repeated supervised exercise sessions in a controlled heated environment Undergo repeated assessments of body water, temperature, heart rate, and exercise performance throughout the study
Trial Details
NCT Number NCT07593014
Lead Sponsor University of Windsor
Conditions Heat Exposure, Exercise Performance, Hydration, Body Fluid Compartments, Creatine Supplementation, Placebo - Control, Plasma Volume
Enrollment 25 participants
Start Date 2026-07-30
Primary Completion 2027-04-30 (estimated)
Study Completion 2027-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-18