Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss

The goal of this clinical trial is to learn about the nature of brain abnormalities associated with excess body fat in healthy adults aged 35-55. The main questions it aims to answer are: * Will excessive fat be associated with brain abnormalities on MRI measures? * Will weight loss change brain health on MRI measures? Participants will: * Self-administer study drug, semaglutide, once a week for 80 weeks * Complete metabolic and basic body measurements * Complete cognitive, mood, and dietary assessments * Complete questionnaires * Undergo MRIs

NCT Number	NCT07592546
Lead Sponsor	Alain Dagher
Conditions	Class I/II Obesity
Enrollment	240 participants
Start Date	2026-08-01
Primary Completion	2028-12-01 (estimated)
Study Completion	2030-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-26