Clinical Trial

Flush, Lyse, Operate

Study acronym: FLO
Not Yet Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is: What is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery? Participants will: * Receive receive saline into their pleural space through an existing chest tube * If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube * If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.
Trial Details
NCT Number NCT07592520
Lead Sponsor Dartmouth-Hitchcock Medical Center
Conditions Complicated Parapneumonic Effusion, Empyema, Pleural
Enrollment 30 participants
Start Date 2026-04
Primary Completion 2027-04 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-05-18