Clinical Trial

Computed Tomography Angiography Based Procedural Planning in PeRcutaneOus Coronary InterVEntion

Study acronym: CT-PROVE
Not Yet Recruiting
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Summary
The goal of this clinical trial is to learn whether coronary CT angiography (CCTA)-guided planning improves the efficiency and outcomes of percutaneous coronary intervention (PCI) in adults with coronary artery disease. It will also evaluate the feasibility and safety of using a CT-based "virtual PCI plan" during coronary interventions. The main questions it aims to answer are: * Does CCTA-guided PCI reduce procedural time, radiation exposure, and contrast dye use compared with standard PCI? * Does CCTA-guided PCI improve procedural outcomes and stent optimization? * How often do operators follow or deviate from the CT-based procedural plan? * What medical problems or complications occur during and after CCTA-guided PCI? Researchers will compare CCTA-guided PCI with standard angiography-guided PCI to determine whether CT-derived procedural planning improves PCI efficiency and clinical outcomes. Participants will: * Undergo PCI guided either by a CCTA-based virtual planning strategy or by standard clinical practice * Attend follow-up assessments at 1 month, 6 months, and 1 year * Undergo routine clinical evaluations and imaging assessments related to their PCI procedure * Be monitored for procedural complications, symptoms, repeat procedures, and cardiovascular outcomes during follow-up The study will also include a parallel observational registry for patients whose coronary lesions are deferred from PCI, to evaluate their long-term clinical outcomes.
Trial Details
NCT Number NCT07592312
Lead Sponsor University of Galway
Conditions Coronary Arteries Disease, Chronic Coronary Syndrome, Acute Coronary Syndromes (ACS), Myocardial Ischemia, Percutaneous Coronary Intervention, Coronary Computed Tomography Angiography
Enrollment 200 participants
Start Date 2026-05-18
Primary Completion 2028-05-20 (estimated)
Study Completion 2028-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-18