Clinical Trial

Confirmatory Trial of Gamma Neurofeedback to Improve Working Memory in Schizophrenia

Not Yet Recruiting Phase 2
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Summary
This study is a confirmatory, double-blind, placebo-controlled randomized clinical trial (RCT) testing whether gamma EEG neurofeedback (EEG-NFB) improves working memory in adults with schizophrenia or schizoaffective disorder. Participants are randomly assigned to receive either active gamma EEG-NFB (real-time feedback of frontal gamma brain activity) or sham EEG-NFB (false pre-recorded feedback), twice weekly for 12 weeks. Working memory (N-back task), brain gamma coherence, and everyday community functioning are assessed at baseline, mid-treatment, end of treatment, and follow-up.
Trial Details
NCT Number NCT07592169
Lead Sponsor University of California, San Diego
Conditions SCHIZOPHRENIA 1 (Disorder), Schizoaffecitve Disorder
Enrollment 104 participants
Start Date 2026-06-01
Primary Completion 2029-11-30 (estimated)
Study Completion 2030-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-18