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NCT07592169

Confirmatory Trial of Gamma Neurofeedback to Improve Working Memory in Schizophrenia

StatusRecruiting
PhasePhase 2
Primary completion (estimated)
Track this trial

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Record History

All 2 versions: 2 with changes below. See every version on ClinicalTrials.gov ↗

  1. Recruitment opened
    • Start date: Jun 1, 2026 to Nov 5, 2026
    • Eligibility criteria expanded, about 2 words
    • Study sites: 0 to 1
  2. Study First Submitted
  • Notable: the plan changed

Endpoints

Primary

N-back 2-back target accuracy (d-prime)
Timeframe: Baseline to Week 12
Frontal gamma coherence during N-back task
Timeframe: Baseline to Week 12
Independent Living Skills Survey (ILSS) total score
Timeframe: Baseline to Week 12

Arms and interventions

Gamma EEG-NFBExperimental

Participants receive real-time gamma EEG neurofeedback targeting frontal gamma coherence (F3 and F4 electrodes, 30-50 Hz) via a CGX wireless 32-electrode headset. Each session includes a 1-minute resting baseline followed by two 15-minute training blocks. Positive reinforcement (images and music) is contingent on meeting an individualized gamma coherence threshold. Sessions are twice weekly for 12 weeks (30 total sessions).

Sham EEG-NFBSham comparator

Participants undergo identical procedures to the active arm including EEG electrode placement and the same session structure, twice weekly for 12 weeks. However, the feedback displayed is pre-recorded from prior participants and has no relationship to the participant's own brain activity. Participants and outcome assessors are blinded to group assignment.

Behavioral: EEG Neurofeedback

Sites

1 site in 1 country

  • UC San Diego School of MedicineLa Jolla, California, United States