Enucleation Ratio as a Novel Predictor of Symptomatic Improvement After HoLEP

The goal of this observational study is to determine whether the rate of prostate tissue removed during surgery relative to the preoperative total prostate volume (referred to as the "enucleation ratio") predicts symptomatic improvement 3 months after HoLEP. The main question it aims to answer is: \- What is the minimum enucleation ratio required to achieve clinically important symptomatic improvement? (Symptomatic improvement is referred to as a threshold of having an International Prostate Symptom Score (IPSS) lower than 8 points, which is determined by the American Urological Association (AUA) and European Association of Urology(EAU)).

NCT Number	NCT07591688
Lead Sponsor	Ondokuz Mayıs University
Conditions	Benign Prostate Obstruction (BPO)
Enrollment	400 participants
Start Date	2026-07-01
Primary Completion	2027-02-01 (estimated)
Study Completion	2027-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-19