Hep Mec Cohort in Zambia

Observational cohort of adults with acute and chronic hepatitis B infection in Zambia, with and without HIV coinfection. Participants join the study at the time of diagnosis and before or at the time when they are starting antiviral treatments and then they are followed up over multiple years to assess changes to their liver and evolution of HBV (and HIV if applicable) infection. All treatments for HBV and HIV are standard per local Ministry of Health guidelines.

NCT Number	NCT07589985
Lead Sponsor	University of Alabama at Birmingham Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Centre for Infectious Disease Research in Zambia, Tropical Gastroenterology and Nutrition Group, University of Zambia, Massachusetts General Hospital, Weill Medical College of Cornell University
Conditions	Hepatitis B, HIV
Enrollment	390 participants
Start Date	2020-09-28
Primary Completion	2029-08-31 (estimated)
Study Completion	2030-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-15