The goal of this clinical trial is to compare two periodontal regenerative treatments in adults with Stage III or IV periodontitis and infrabony periodontal defects ≥3 mm.
The study aims to determine whether hyaluronic acid and polynucleotides (Regenfast®) combined with bovine bone graft material (Bio-Oss®) provides similar or improved periodontal regeneration compared with enamel matrix derivative proteins (Emdogain®) combined with Bio-Oss®.
Researchers will evaluate:
* Periodontal healing and bone regeneration
* Changes in probing depth, clinical attachment level, gingival recession, and tooth mobility
* Radiographic bone fill
* Survival of treated teeth after 1, 3, and 5 years
Participants will:
* Receive initial periodontal treatment and oral hygiene instruction
* Undergo clinical and radiographic evaluation
* Receive minimally invasive periodontal regenerative surgery under local anesthesia
* Be randomly assigned to receive either Regenfast® + Bio-Oss® or Emdogain® + Bio-Oss®
* Attend follow-up visits with periodontal examinations and radiographs over 5 years