Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?

After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and bacteria may affect healing. This study will investigate how different collagen-based biomaterials behave when exposed in the mouth, evaluating healing, bone changes, bacterial contamination, and patient experience. Sixty patients will be included in a randomized clinical trial comparing two commonly used biomaterials and natural healing. The results will help clinicians choose safer and more effective treatments, improving outcomes for patients undergoing tooth extraction and future implant rehabilitation.

NCT Number	NCT07589751
Lead Sponsor	Pontificia Universidade Católica do Rio Grande do Sul Collaborators: Geistlich Pharma AG
Conditions	Tooth Extraction Site Healing, Alveolar Ridge Preservation
Enrollment	60 participants
Start Date	2026-05
Primary Completion	2027-05 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-05-15