Pulse Pressure and Outcomes After Out-of-Hospital Cardiac Arrest

STEP-PRESS is a predefined exploratory observational substudy nested within the STEPCARE trial. The study will evaluate whether early low pulse-pressure burden after out-of-hospital cardiac arrest is associated with early mortality and selected biomarker outcomes. Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure using recorded STEPCARE blood-pressure values. The primary exposure is cumulative hours with pulse pressure below 40 mmHg during the first 12 hours after randomization. The primary outcome is all-cause mortality from the 12-hour landmark to day 7.

NCT Number	NCT07586878
Lead Sponsor	Region Skane
Conditions	Out-of-hospital Cardiac Arrest (OHCA), Post-Cardiac Arrest Syndrome
Enrollment	3,500 participants
Start Date	2023-08-17
Primary Completion	2026-05-19 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-22