Clinical Trial

Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

Study acronym: LS-RF
Not Yet Recruiting
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Summary
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether laparoscopic splenectomy can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .
Protocol Amendment History 1 change
critical Primary endpoint(s) modified 2026-05-19
Trial Details
NCT Number NCT07585773
Lead Sponsor Northern Jiangsu People's Hospital
Conditions Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue
Enrollment 30 participants
Start Date 2026-05-01
Primary Completion 2029-02-28 (estimated)
Study Completion 2029-02-28 (estimated)
Updated on ClinicalTrials.gov 2026-05-18