IBIS - Investigating Reliability of BIS and SEDLINE Monitoring in Children With Developmental and Epileptic Encephalopathies (DEE).

When children have surgery, anaesthetists carefully monitor the depth of anaesthesia by using sensors on the forehead that measure brain activity, also known as processed electroencephalogram (pEEG). These monitors are routinely used in paediatric anaesthesia; however, investigators do not know if they work accurately in babies and young children with seizure disorders or on anti-seizure medications. Children with developmental and epileptic encephalopathies may need anaesthesia for tests or procedures. It is important that their treating doctors understand whether these monitors truly reflect how awake or asleep the children are. This study aims to compare a child's electrical brain activity using two commonly used devices in paediatric anaesthesia with the conventional 21-lead EEG patterns in children with seizure disorders. The results of this research may help improve the safety and perioperative care of children with seizure disorders who require general anaesthesia in the future.

NCT Number	NCT07585643
Lead Sponsor	Telethon Kids Institute Collaborators: Child and Adolescent Health Service - Perth, Feculdade de Medicina da Universidade de Sao Paulo - Brasil, University of Sao Paulo General Hospital
Conditions	Epileptic Encephalopathy, Early Infantile Epileptic Encephalopathy, Infantile Spasm, Developmental and Epileptic Encephalopathies
Enrollment	40 participants
Start Date	2026-09-03
Primary Completion	2029-09-03 (estimated)
Study Completion	2029-09-04 (estimated)
Updated on ClinicalTrials.gov	2026-07-17