Clinical Trial

Efficacy and Safety of Overnight Occlusive HA35 Gel for Facial Aesthetic Improvement

Study acronym: HA35-FACIAL
Not Yet Recruiting
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Record status
This record was last updated May 13, 2026 (before its estimated June 20, 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of overnight occlusive topical application of 10% high-concentration 35 kDa hyaluronan (HA35) gel for facial aesthetic improvement. Eligible participants will receive overnight occlusive application once every 2 days for a total of 5 treatments over 10 days. The primary objectives are to assess changes in facial subcutaneous fat appearance, inflammatory erythema, skin radiance, and nasal alar pore enlargement after 1 and 5 applications. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive aesthetic intervention.
Trial Details
NCT Number NCT07584811
Lead Sponsor Nakhia Impex LLC
Conditions Facial Subcutaneous Fat, Facial Erythema, Skin Dullness, Nasal Alar Pore Enlargement, Facial Aesthetic Improvement
Enrollment 30 participants
Start Date 2026-05-01
Primary Completion 2026-06-20 (estimated)
Study Completion 2026-07-20 (estimated)
Updated on ClinicalTrials.gov 2026-05-13