Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery

This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina. Stress from surgery and anesthesia can increase sympathetic activity and inflammation, which may lead to heart stress. This pragmatic clinical trial will compare patients who are prescribed propranolol as part of their routine care with those who are not. Researchers will analyze blood samples and surgical tissues collected during normal treatment to observe changes in heart health and the tumor microenvironment.

NCT Number	NCT07583134
Lead Sponsor	Chang-Ik Yoon Collaborators: Seoul St. Mary's Hospital
Conditions	Breast Cancer, Myocardial Injury After Noncardiac Surgery (MINS)
Enrollment	100 participants
Start Date	2026-05-26
Primary Completion	2028-05-23 (estimated)
Study Completion	2033-05-24 (estimated)
Updated on ClinicalTrials.gov	2026-05-15