EEG Prediction and Clinical Efficacy of tDCS in Fibromyalgia.

The purpose of this randomized controlled trial is to investigate the non-inferiority, and possible superiority, of a high-dose home-based tDCS protocol compared with a conventional home-based protocol, and to assess its cost-effectiveness, in patients with fibromyalgia. As complementary goals, we aim to assess the predictive value of baseline EEG for clinical response to high-dose home-based tDCS treatment; and to describe the effectiveness of a high-dose home-based protocol applied to the motor cortex (M1) versus the dorsolateral prefrontal cortex (DLFPC) in patients with fibromyalgia.

NCT Number	NCT07583056
Lead Sponsor	Ionclinics & Deionic SL Collaborators: Hospital Clínico Universitario de Valencia
Conditions	Fibromyalgia (FM)
Enrollment	250 participants
Start Date	2026-07-08
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-15