A Novel Two-Tooth Clip for ESD and EFTR of GIST

This study is designed to evaluate the efficacy and safety of a novel two-tooth endoscopic clip, utilized in a "clip with line" traction configuration, during endoscopic resection procedures (ESD and EFTR) of GIST. The novel clip's dual-tooth design is intended to provide a more secure anchor on the lesion, enabling effective counter-traction when combined with a line. The primary aim is to determine if this method improves submucosal dissection efficiency compared to conventional ESD. A secondary aim is to evaluate the performance of the same clip system for full-thickness or mucosal defect closure.

NCT Number	NCT07581977
Lead Sponsor	Affiliated Hospital to Academy of Military Medical Sciences
Conditions	GIST - Gastrointestinal Stromal Tumor
Enrollment	60 participants
Start Date	2026-04-24
Primary Completion	2027-04-24 (estimated)
Study Completion	2027-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-22