Efficacy and Safety of HA35 Gel for Ultra-Rapid Skin Pruritus Relief

This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel for ultra-rapid relief of moderate-to-severe skin pruritus from diverse etiologies (eczema, neurodermatitis, insect bites, urticaria, postoperative wound itch). Eligible participants will receive a single topical application of HA35 gel. The primary objective is to assess pruritus relief at 10 seconds, 45 minutes, 8 hours, 12 hours, and 24 hours post-application. Safety and local skin tolerability will be evaluated throughout the observation period. This is a minimal-risk, non-pharmacological, non-invasive intervention.

NCT Number	NCT07580911
Lead Sponsor	Nakhia Impex LLC
Conditions	Skin Pruritus, Itch, Eczema Itch, Neurodermatitis, Insect Bite Itch, Urticaria, Postoperative Wound Pruritus
Enrollment	30 participants
Start Date	2026-06-20
Primary Completion	2026-07-20 (estimated)
Study Completion	2026-08-20 (estimated)
Updated on ClinicalTrials.gov	2026-05-12