PHGG-LGG Synbiotic in Pediatric Functional Constipation

This prospective, randomized controlled open-label trial evaluated the efficacy of a synbiotic consisting of partially hydrolyzed guar gum (PHGG) and Lacticaseibacillus rhamnosus GG (LGG) on clinical outcomes and gut microbiota in children with functional constipation. Children aged 4-16 years meeting Rome IV criteria were randomized to receive either synbiotic supplementation plus dietary counseling or dietary counseling alone for 12 weeks. Clinical outcomes, gastrointestinal symptoms, and stool microbiota (shotgun metagenomics) were assessed at baseline and at week 12.

NCT Number	NCT07580729
Lead Sponsor	Eskisehir Osmangazi University Collaborators: Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Conditions	Constipation - Functional
Enrollment	52 participants
Start Date	2024-08-01
Primary Completion	2024-12-01 (estimated)
Study Completion	2024-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-12