Microplastics in Brain Hematomas and Neurological Outcomes After Intracerebral Hemorrhage

This observational study investigates the presence of micro- and nanoplastics in surgically removed intracerebral hematomas and their association with neurological outcomes in patients with spontaneous intracerebral hemorrhage. Microplastics have recently been identified in human tissues and are increasingly recognized as potential contributors to inflammation and vascular dysfunction. However, their role in cerebrovascular diseases, particularly intracerebral hemorrhage, remains unknown. Patients undergoing surgical hematoma evacuation will be enrolled. Brain tissue and blood samples will be analyzed using advanced spectroscopic and imaging techniques to detect and characterize micro- and nanoplastics. The study aims to evaluate whether the presence of these particles is associated with increased inflammation, worse neurological outcomes, and higher risk of adverse cerebrovascular events. This research may provide novel insights into the impact of environmental pollutants on brain vascular disease and patient prognosis.

NCT Number	NCT07580326
Lead Sponsor	University of Campania Luigi Vanvitelli Collaborators: Federico II University, IRCCS Multimedica
Conditions	Intracerebral Hemorrhage, Brain Hematoma
Enrollment	150 participants
Start Date	2024-06-01
Primary Completion	2025-01-01 (estimated)
Study Completion	2026-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-02