CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients

This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients. The primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement. The study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.

NCT Number	NCT07579728
Lead Sponsor	Istanbul University - Cerrahpasa
Conditions	Critical Illness, Frailty, Intensive Care Unit (ICU)
Enrollment	138 participants
Start Date	2026-04-30
Primary Completion	2026-06-30 (estimated)
Study Completion	2026-07-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-09